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It is characterized by the formation of new lisinopril pill of infection and the development of increased allergenicity of the body to adverse factors. The body's hypersensitivity persists for quite a long time, even after the infection has stopped, which is one of the leading pathogenetic signs of brucellosis. In fact, this stage is a chronic period of the disease with a long course (up to 3 years or more) and periodic relapses. Stage 5 (residual effects). It is characterized by the presence of irreversible consequences in the body even after the complete relief of the infection. Among such changes, one can distinguish - destruction and deformation of bones, joints, allergies, disorders of the nervous system.

The most severe brucellosis is caused by Brucella melitensis, which is usually carried by cattle.

After the disease, a relatively short-term immunity is formed in a person - for 3-5 years, after which re-infection is possible. The greatest number of cases of morbidity is recorded in countries with a wide distribution of animal husbandry, especially in the absence of pasteurization. The peak incidence is mainly in the winter-spring period.

The incubation period of brucellosis (from infection to the first signs of the disease) is from 7 to 28 days.

If a person becomes a latent carrier, then the incubation period can last up to 3 months. In elderly people, the onset of the disease is often less pronounced, but symptoms such as fever, insomnia, headaches, and weakness gradually increase. Also, the patient may have problems with stool (constipation), dry mouth, constant thirst. Since brucellosis is a multi-organ disease, its development can lead to a number of serious health problems.

The causative agent of brucellosis is a Gram-negative non-motile bacterium of the genus Bru.cella (Brucella), which are able to parasitize inside cells. For humans, pathogenic, i.e. causing the disease, of which there are four types: The most severe course of the disease is caused by Brucella melitensis. Bacteria are excreted into the external environment with urine, feces, milk, blood of the carrier, amniotic fluid. In addition, the common fly Stomaxys calcitrans (autumn fly) can serve as a carrier of infection.

The penetration of bacteria into the body occurs through microtrauma of the skin, mucous membranes, or by eating contaminated food, especially raw milk or other dairy products made from unpasteurized milk. Aerogenic penetration of bacteria into the body is also possible, which is important in conditions of poor ventilation in large flocks. Brucella can live stably in the environment - in the ground, manure, on the wool of livestock, even at low temperatures, but they die when exposed to disinfectants or boiling.

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At risk of infection are veterinarians, farmers, meat-packing workers, as well as enterprises for the procurement of leather and wool. Primary-latent - characterized by small clinical manifestations (slightly enlarged lymph nodes, elevated body temperature), which increase or move to the next stage of the disease when immunity is weakened. The patient's ability to work is preserved.

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Acute septic - characterized by high body temperature with large fluctuations during the day, chills, excessive sweating. At the same time, the patient feels well enough and maintains working capacity. A week later, without help, he observes an increase in the spleen and liver, the lymph nodes are moderately enlarged, some are slightly painful. In the absence of lisinopril pill, the duration of the phase can last more than 30 days.

Primary chronic (with metastases). It can develop bypassing the acute phase of the development of the disease, or as an outcome of the acute septic period. It is characterized by a sluggish course with all the signs characteristic of brucellosis.

  1. Secondary chronic (with metastases). According to the symptoms, the primary and secondary chronic forms of the disease do not differ.
  2. However, there are changes in various organs and systems - first of all, the liver and spleen increase, the functioning of the musculoskeletal system is disrupted, and then disorders of the nervous and genitourinary systems develop. Primary latent.
  3. The most effective against Brucella are the following groups of antibiotics - fluoroquinolones, tetracyclines, aminoglycosides. To increase efficiency, 2 antibiotics from different groups are used, one of which should act on the pathogen at the cellular level.

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Thus, the following combinations of taking antibiotics against brucellosis are distinguished: Please note that most antibiotics have contraindications - children under 15 years of age, pregnant women, lactation and others. To stabilize the patient's health and speed up recovery, the following medications are used:

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Lisinopril - used to relieve pain in the joints, with various neuralgia, neuritis - novocaine blockade with a 1% solution topically, or intravenous administration of novocaine 0.25%.

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The vaccine against brucellosis is used every year by a smaller number of specialists, which is associated with an increased number of adverse effects, from which one can distinguish - a decrease in the reactivity of immunity and a large number of autoimmune reactions to serum ingredients.

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Vitamins - are used to strengthen the immune system and maintain the functioning of the cardiovascular system. Vitamin C (ascorbic acid) and B vitamins are especially useful in this case. During a stable remission of the chronic form of the disease and the post-brucellosis period, the following methods of physiotherapy are prescribed: Spa treatment also has a beneficial effect on the body.

It is used only in cases where it is necessary to eliminate a defect in the functioning of the musculoskeletal system, or in severe lesions of internal organs, the treatment of which has not been successful in a conservative way. The lethality of the outcome of brucellosis during the observation of the disease was no more than 2%. Moreover, this percentage is due mainly to severesevere consequences and complications of the disease - endocarditis, infectious-toxic shock.

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